【摘 要】目的：探讨血清尿酸 (UA)、乳酸脱氢酶﹙LDH﹚与子痫前期或子痫致可逆性后部白质脑病综合征﹙RPLS﹚发病的关系及临床意义。方法：分析27例子痫前期或子痫并发RPLS患者的临床资料，测定血清UA、LDH及其它生化指标，与同期住院行MRI检查结果阴性的子痫前期或子痫患者30例相比较。分析血清UA、LDH水平与RPLS发病的相关性。结果：RPLS组患者血清UA、LDH﹙472±18μmo/L，423±68 U/L﹚水平显著高于对照组﹙365±16μmo/L，286±54 U/L﹚﹙均P<0.05﹚。Pearson相关分析显示，血清UA、LDH水平与RPLS发病呈正相关﹙r=0.218， P=0.014；r=0.426， P=0.002﹚。结论：RPLS患者可能存在有更为严重的血管内皮功能损伤，联合检测血清UA、LDH对于RPLS的早期诊断具有一定的临床意义。

    【关键词】子痫；可逆性后部白质脑病综合征；尿酸；乳酸脱氢酶；脑水肿

    [Abstract]0bjective：To evaluate the clinical value of the uric acid and lactic dehydrogenase in preeclampsia-eclampsia patients with Reversible Posterior Leukoencephalolpathy Syndrome(RPLS) in preeclampsia-eclampsia patients.Methods： 27 preeclampsia-eclarnpsia patients with RPLS were divided into RPLS group and 30 preeclampsia-clampsia controls with normal MRI findings were divided into control group. LDH ......