盐酸多奈哌齐治疗阿尔兹海默病的临床效果(1)
[摘要]目的 研究应用盐酸多奈哌齐(HCI)治疗阿尔兹海默病(AD)患者的临床效果。方法 选取2015年3月～2019年3月我院收治的60例AD患者作为研究对象，采用随机数字表法，分为观察组和对照组，每组各30例。对照组采用常规药物治疗，观察组给予HCI治疗，比较两组治疗效果、治疗前后简明精神状态检查量表(MMSE)和日常生活能力量表(ADL)评分、不良反应发生情况。结果 治疗后，观察组总有效率高于对照组，观察组MMSE评分高于对照组，ADL评分低于对照组，观察组不良反应总发生率低于对照组，差异有统计学意义(P<0.05)。结论 将HCI应用到AD治疗中，临床效果显著，患者的精神状态、日常生活能力均得到了明显改善，且很少出现不良反应，极具临床推广价值。
[关键词]阿尔兹海默病;盐酸多奈哌齐;精神状态检查量表;日常生活能力量表
[中图分类号] R749.1 [文献标识码] A [文章编号] 1674-4721(2019)12(a)-0035-03
Clinical effect of Donepezil Hydrochloride in the treatment of Alzheimer′s disease
ZHAI Yue-fang LI Hua ZHAO Chun-zhi
Department of Geriatrics， Taizhou People′s Hospital， Jiangsu Province， Taizhou 225300， China
[Abstract] Objective To study the clinical effect of Donepezil Hydrochloride (HCI) in the treatment of patients with Alzheimer′s disease (AD). Methods A total of 60 cases of patients with AD admitted to our hospital from March 2015 to March 2019 were selected as research objects， they were divided into observation group and control group by random number table method， with 30 cases in each group. The control group was treated with conventional drugs， while the observation group was treated with HCI. The therapeutic effect， mini-mental state examination scale (MMSE) and activities of daily living scale (ADL) scores before and after treatment， and the occurrence of adverse reactions were compared between the two groups. Results After treatment， the total effective rate of the observation group was higher than that of the control group; the MMSE score in the observation group was higher than that in the control group， and the ADL score was lower than that in the control group; the total incidence of adverse reactions in the observation group was lower than that of the control group， the differences were statistically significant (P<0.05). Conclusion The application of HCI in the treatment of AD has a significant clinical effect. The mental state and daily living ability of the patients have been significantly improved. Moreover， there are few adverse reactions and it has great clinical promotion value.
[Key words] Alzheimer′s disease; Donepezil Hydrochloride; Mental state examination scale; Daily life ability scale
阿爾茨海默病(AD)，临床表现为记忆障碍、失语、失用、视空间技能损害、执行功能障碍等全面性痴呆，发病原因至今未明。发病年龄在65岁以下被称为早老性痴呆，65岁以上则称为老年性痴呆，临床上，以70岁以上患者居多[1]。AD很大程度上影响了老年患者的日常工作及生活，需要引起社会各界重视，给予老年人更多关怀。将盐酸多奈哌齐(HCI)应用到AD患者中，治疗效果显著，能够使AD患者精神状态得到明显改善，提高日常生活质量。HCI经美国食品与药物管理局(FDA)批准，在AD治疗中广泛应用，达到了非常好的临床效果。本实验通过对60例AD患者进行分组研究，着重分析HCI在AD患者临床治疗中的应用效果，为后续研究提供借鉴。, 百拇医药(翟月芳 李华 赵春芝)
[关键词]阿尔兹海默病;盐酸多奈哌齐;精神状态检查量表;日常生活能力量表
[中图分类号] R749.1 [文献标识码] A [文章编号] 1674-4721(2019)12(a)-0035-03
Clinical effect of Donepezil Hydrochloride in the treatment of Alzheimer′s disease
ZHAI Yue-fang LI Hua ZHAO Chun-zhi
Department of Geriatrics， Taizhou People′s Hospital， Jiangsu Province， Taizhou 225300， China
[Abstract] Objective To study the clinical effect of Donepezil Hydrochloride (HCI) in the treatment of patients with Alzheimer′s disease (AD). Methods A total of 60 cases of patients with AD admitted to our hospital from March 2015 to March 2019 were selected as research objects， they were divided into observation group and control group by random number table method， with 30 cases in each group. The control group was treated with conventional drugs， while the observation group was treated with HCI. The therapeutic effect， mini-mental state examination scale (MMSE) and activities of daily living scale (ADL) scores before and after treatment， and the occurrence of adverse reactions were compared between the two groups. Results After treatment， the total effective rate of the observation group was higher than that of the control group; the MMSE score in the observation group was higher than that in the control group， and the ADL score was lower than that in the control group; the total incidence of adverse reactions in the observation group was lower than that of the control group， the differences were statistically significant (P<0.05). Conclusion The application of HCI in the treatment of AD has a significant clinical effect. The mental state and daily living ability of the patients have been significantly improved. Moreover， there are few adverse reactions and it has great clinical promotion value.
[Key words] Alzheimer′s disease; Donepezil Hydrochloride; Mental state examination scale; Daily life ability scale
阿爾茨海默病(AD)，临床表现为记忆障碍、失语、失用、视空间技能损害、执行功能障碍等全面性痴呆，发病原因至今未明。发病年龄在65岁以下被称为早老性痴呆，65岁以上则称为老年性痴呆，临床上，以70岁以上患者居多[1]。AD很大程度上影响了老年患者的日常工作及生活，需要引起社会各界重视，给予老年人更多关怀。将盐酸多奈哌齐(HCI)应用到AD患者中，治疗效果显著，能够使AD患者精神状态得到明显改善，提高日常生活质量。HCI经美国食品与药物管理局(FDA)批准，在AD治疗中广泛应用，达到了非常好的临床效果。本实验通过对60例AD患者进行分组研究，着重分析HCI在AD患者临床治疗中的应用效果，为后续研究提供借鉴。, 百拇医药(翟月芳 李华 赵春芝)