病灶扩大刮除联合软骨下植骨、骨水泥填充治疗膝关节周围骨巨细胞瘤的临床效果(1)
[摘要]目的 探讨病灶扩大刮除联合软骨下植骨、骨水泥填充治疗膝关节周围骨巨细胞瘤(GCT)的临床效果。方法选取2009年2月～2019年2月我院收治的60例膝关节周围GCT患者作为研究对象，采用随机數字表法分为对照组(病灶扩大刮除术)和观察组(病灶扩大刮除术联合软骨下植骨、骨水泥填充治疗)，每组各30例。比较治疗后两组的Enneking肢体功能评分、应用可行性及术后并发症、复发率等情况。结果 治疗后，观察组的Enneking肢体功能总体评分高于对照组，差异有统计学意义(P<0.05);观察组的并发症总发生率为6.67%，低于对照组的36.67%，差异有统计学意义(P<0.05);观察组的复发率为3.33%，低于对照组的16.67%，差异有统计学意义(P<0.05)。结论 对膝关节周围GCT患者，采取病灶扩大刮除术联合软骨下植骨、骨水泥填充治疗，可有效改善患者的生活质量，提高患者肢体功能恢复的速度，并发症及复发率较低，有较高临床应用价值。
[关键词]膝关节周围骨巨细胞瘤;病灶扩大刮除术;软骨下植骨;骨水泥填充
[中图分类号] R738 [文献标识码] A [文章编号] 1674-4721(2019)8(a)-0080-03
[Abstract] Objective To investigate the clinical effect of extended curettage combined with subchondral bone grafting and cement filling in the treatment of giant cell tumors (GCT) of bone around the knee joint. Methods From February 2009 to February 2019， 60 patients with GCT of bone around the knee joints in our hospital were selected and divided into the control group (focal enlargement curettage) and the observation group (focal enlargement curettage combined with subchondral bone grafting and bone cement filling)， 30 cases in each group. Enneking limb function score， feasibility of application， postoperative complications and recurrence rate were compared between two groups. Results After treatment， the Enneking limb function score of the observation group was higher than that of the control group， with statistical significance (P<0.05); the total incidence of complications in the observation group was 6.67%， lower than 36.67% of the control group， with statistical significance (P<0.05); the recurrence rate of the observation group was 3.33%， lower than 16.67% of the control group， with statistical significance (P<0.05). Conclusion For patients with GCT of bone around the knee joint， enlarged curettage combined with subchondral bone grafting and bone cement filling can effectively improve the quality of life， speed up the recovery of limb function， lower complications and recurrence rate， and have higher clinical application value.
[Key words] Giant cell tumor of bone around knee joint; Enlarged curettage; Subchondral bone grafting; Cement filling
骨巨细胞瘤(GCT)属于原发骨肿瘤疾病，主要特征为侵袭性较强，对骨质的溶蚀造成破坏性损伤，如未及时给予治疗，延发对全身骨质系统造成影响，对患者的生活质量及生命安全均造成极大威胁[1]。目前，临床对膝关节周围GCT患者的主要治疗原则为刮除、切除治疗[2]。临床资料显示，GCT的发病率占我国原发骨肿瘤发病率的6%左右，且发病率高于国外欧美国家，根据国内外的研究现状应多做收集工作，最大限度的清除肿瘤组织，保证后期患者的生活质量为治疗的终极目的，为探讨何种治疗方式用于此类疾病患者可取得较佳的治疗效果，特选取我院收治的60例膝关节周围GCT患者作为研究对象比较分析，现报道如下。, http://www.100md.com(刘成 陈树鑫 沈晖扬)
[关键词]膝关节周围骨巨细胞瘤;病灶扩大刮除术;软骨下植骨;骨水泥填充
[中图分类号] R738 [文献标识码] A [文章编号] 1674-4721(2019)8(a)-0080-03
[Abstract] Objective To investigate the clinical effect of extended curettage combined with subchondral bone grafting and cement filling in the treatment of giant cell tumors (GCT) of bone around the knee joint. Methods From February 2009 to February 2019， 60 patients with GCT of bone around the knee joints in our hospital were selected and divided into the control group (focal enlargement curettage) and the observation group (focal enlargement curettage combined with subchondral bone grafting and bone cement filling)， 30 cases in each group. Enneking limb function score， feasibility of application， postoperative complications and recurrence rate were compared between two groups. Results After treatment， the Enneking limb function score of the observation group was higher than that of the control group， with statistical significance (P<0.05); the total incidence of complications in the observation group was 6.67%， lower than 36.67% of the control group， with statistical significance (P<0.05); the recurrence rate of the observation group was 3.33%， lower than 16.67% of the control group， with statistical significance (P<0.05). Conclusion For patients with GCT of bone around the knee joint， enlarged curettage combined with subchondral bone grafting and bone cement filling can effectively improve the quality of life， speed up the recovery of limb function， lower complications and recurrence rate， and have higher clinical application value.
[Key words] Giant cell tumor of bone around knee joint; Enlarged curettage; Subchondral bone grafting; Cement filling
骨巨细胞瘤(GCT)属于原发骨肿瘤疾病，主要特征为侵袭性较强，对骨质的溶蚀造成破坏性损伤，如未及时给予治疗，延发对全身骨质系统造成影响，对患者的生活质量及生命安全均造成极大威胁[1]。目前，临床对膝关节周围GCT患者的主要治疗原则为刮除、切除治疗[2]。临床资料显示，GCT的发病率占我国原发骨肿瘤发病率的6%左右，且发病率高于国外欧美国家，根据国内外的研究现状应多做收集工作，最大限度的清除肿瘤组织，保证后期患者的生活质量为治疗的终极目的，为探讨何种治疗方式用于此类疾病患者可取得较佳的治疗效果，特选取我院收治的60例膝关节周围GCT患者作为研究对象比较分析，现报道如下。, http://www.100md.com(刘成 陈树鑫 沈晖扬)