巢式病例对照研究在HIS真实世界参麦注射液疑似过敏因素分析中的应用(4)
WANG Lian-xin1， TANG Hao2， XIE Yan-ming1*， YANG Wei1
(1.Institute of Basic Research in Clinical Medcine， China Academy of Chinese Medical Sciences， Beijing 100700， China；
2. Renmin University of China， Beijing 100872， China)
[Abstract] Parenterally administered Shenmai， made from constituents of Ginseng Rubra Radix and Ophiopogonis Radix has， confirmed by modern pharmacological studies， the function of increasing cardiac hypoxia tolerance and anti arrhythmic and antibacterial properties. However， parenterally administered Shenmai is also prone to cause allergic reactions， which is clearly a safety issue. NCCSs combine elements from case-control and cohort studies. HIS data provides real world clinical information on the use of parenterally administered Shenmai. To explore suspected allergic factors this article compares specific information of those who showed allergies to those who didn't in the real world clinical application based on HIS data from 20 nationwide hospitals. Data includes age， gender， severity and type of allergic response， dosage， solvents used in the medication′s preparation and drugs used in combination with parenterally administered Shenmai. Whilst this methodology is a possible route of exploration， ultimately pharmaceutical experiments and prospective clinical studies are required to identify and confirm factors related to allergic reactions.
[Key words] nested case control study； hospital information system real world； parenterally administered Shenmai； questionable allergic factors； logistic regression
doi：10.4268/cjcmm20131820, http://www.100md.com(王连心 唐浩 谢雁鸣 杨薇)
(1.Institute of Basic Research in Clinical Medcine， China Academy of Chinese Medical Sciences， Beijing 100700， China；
2. Renmin University of China， Beijing 100872， China)
[Abstract] Parenterally administered Shenmai， made from constituents of Ginseng Rubra Radix and Ophiopogonis Radix has， confirmed by modern pharmacological studies， the function of increasing cardiac hypoxia tolerance and anti arrhythmic and antibacterial properties. However， parenterally administered Shenmai is also prone to cause allergic reactions， which is clearly a safety issue. NCCSs combine elements from case-control and cohort studies. HIS data provides real world clinical information on the use of parenterally administered Shenmai. To explore suspected allergic factors this article compares specific information of those who showed allergies to those who didn't in the real world clinical application based on HIS data from 20 nationwide hospitals. Data includes age， gender， severity and type of allergic response， dosage， solvents used in the medication′s preparation and drugs used in combination with parenterally administered Shenmai. Whilst this methodology is a possible route of exploration， ultimately pharmaceutical experiments and prospective clinical studies are required to identify and confirm factors related to allergic reactions.
[Key words] nested case control study； hospital information system real world； parenterally administered Shenmai； questionable allergic factors； logistic regression
doi：10.4268/cjcmm20131820, http://www.100md.com(王连心 唐浩 谢雁鸣 杨薇)